Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.
An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.
Searching Both is inclusive of interventional and observational studies.
|Eligible Ages||18 Years and Over|
- - Age ≥18 year-old.
- - Patients who give informed consent to the study.
- - Suboptimal pain control with regular analgesics.
- - Inoperable cancer of pancreas.
- - Patients who refuse to give consent.
- - Patients aged <18 years.
- - EUS not possible due to: Problem related to scope insertion such as trismus, stenosis of the upper GI tract Coagulopathy with INR >1.5 or platelet count < 70.
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.
Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.
Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.
Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.
|The University of Hong Kong|
The person who is responsible for the scientific and technical direction of the entire clinical study.
|Ka Wing Ma, MBBS, MS|
|Principal Investigator Affiliation||The University of Hong Kong|
Category of organization(s) involved as sponsor (and collaborator) supporting the trial.
The disease, disorder, syndrome, illness, or injury that is being studied.
|Cancer of Pancreas, Pancreatic Neoplasms, Pain, Cancer-Associated Pain, Pain Management|
The aim of this study is to compare the efficacy of EUS-guided CPN versus radiofrequency ablation in patients with pain related to pancreatic cancer. By performing a randomized controlled trial, the clinical outcomes and cost-effectiveness of this new RFA treatment approach can be evaluated.
Active Comparator: EUS-CPB
Chemical ablation of the coeliac plexus
Active Comparator: EUS-CPA
Radiofrequency ablation of the coeliac plexus
Drug: - 98% dehydrated alcohol
coeliac plexus is identified and punctured Injection of 10 mL of .25% bupivacaine, followed by 10 mL of 98% dehydrated alcohol.
Device: - 19G EUSRA needle, Taewoong Medical, Korea
10W-30W RFA will be applied unilaterally or bilaterally depends on individual anatomical characteristics for 10-50s Complete ablation of coeliac plexus nervous tissue is confirmed by appearance of air-bubble ultrasound scan
Contact a Trial Team
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.